SME may refer to:
Economics
- Small and medium-sized enterprises, businesses whose personnel numbers fall below certain limits
- Social market economy, an economic model used in Europe
- Socialist market economy, an economic system of the People's Republic of China
Organizations
- S.M. Entertainment, a South Korean record label
- SME (society), formerly Society of Manufacturing Engineers
- SME Limited, a British maker of audio pick-up arms (tonearms) and turntables
- Sony Music Entertainment, an American recording company, subsidiary of Sony Corporation of America
- Society for Mining, Metallurgy, and Exploration
Science and technology
- Situational method engineering, the construction of methods which are tuned to specific situations of development projects
- Solar Mesosphere Explorer, a NASA artificial satellite in Earth orbit from 1981â"1989
- Standard-Model Extension, in quantum field theory
- Subsequent memory effect, in cognitive psychology
- Surface-mount equipment, machines for the assembly of surface-mount technology electronic components
- Soy methyl ester, biodiesel created from soybean oil
- Sevomethyl ether, USP Sevoflurane Related Compound B
Computing
- Secure Memory Encryption, an AMD real time memory encryption technology
- Structure mapping engine, in artificial intelligence and cognitive science
- SME Server, a Linux firewall/server distribution
- SIGNAL Meta under Eclipse, an EMF-based metamodel of the SIGNAL programming language
Music
- Sloppy Meateaters, a former band from Rome, Georgia, US
- Spontaneous Music Ensemble, a loose collection of musicians convened beginning in the mid-1960s
Other uses
- SME (newspaper), a Slovak daily newspaper
- Subject-matter expert, a person who is an expert in a particular area or topic