Fathead may refer to:
Fish
- Fathead carp
- Fathead minnow
- Fathead sculpin
- Cubiceps
- Trochocopus pulcher of the family Labridae
- Psychrolutes microporos of the family Psychrolutidae
Music
- David "Fathead" Newman (1933-2009), American jazz and R&B saxophonist
- Fathead (album), Newman's debut release
- Fathead (musician) (c. 1960รข"1988), Jamaican dance hall deejay
- Fathead (band), Canadian blues band
Other uses
- Fathead (brand), a graphics company specializing in sports decorations and custom wall graphics
- Fat Head, a documentary criticizing Super Size Me and seeking to refute the lipid hypothesis